Musculoskeletal Health (Formerly Physical Therapy)

Dr. Sylvia Thomas

Dr. Thomas had received her medical degree from the Centro de Esino Superior in Valenca, Brazil. She completed her specialization in Clinical Hematology at the Federal University Fluminese in Niteroi, Brazil in 2001. Later, she completed her Masters in Clinical Medicine and fulfilled a Doctorate in Medical Radiology in 2013. Dr. Thomas has over 30 years of experience working with persons with bleeding disorders and has developed a program in which radiosynoviorthesis, provided for patients throughout Brazil. Herself and her team performed up to 1,500 radiosynoviorthesis procedures in hemophilic joints, in both adults and children. She utilizes the HJHS along with many other hemophilia-specific clinic and radiologic tools to assess joint health in her patients with hemophilia.

Key Publications

CV: (Curriculum Vitae):

VULPEN, LIZE F. D.; Thomas, Sylvia ; KENY, SWAPNIL A. ; MOHANTY, SHUBHRANSHU S. . Synovitis and synovectomy in haemophilia. HAEMOPHILIA, v. 27, p. 96-102, 2021.

GUEDES, VANESSA GIROTO ; WACHHOLZ, PATRICK ALEXANDER ; Thomas, Sylvia ; SOUZA, SERGIO AUGUSTO LOPES . Monitoring the joint health of patients with haemophilia in a middle-income country: Considerations on the use of the Haemophilia Joint Health Score. HAEMOPHILIA, v. 00 1, p. 1-3, 2020.

Thomas, Sylvia; GABRIEL, M. B. ; ASSI, P. E. ; BARBOZA, M. ; PERRI, M. L. P. ; LAND, M. G. P. ; DA COSTA, E. S. . Radioactive synovectomy with Yttrium90 citrate in haemophilic synovitis: Brazilian experience. Haemophilia (Oxford. Print), v. 17, p. e211-e216, 2011.


TORRES BERDEGUEZ, MIRTA BÁRBARA; Thomas, Sylvia ; RAFFUL, PATRICIA ; ARRUDA SANCHEZ, TIAGO ; MEDEIROS OLIVEIRA RAMOS, SUSIE ; ALBERNAZ, MARTA SOUZA ; VASCONCELLOS DE SÁ, LIDIA ; LOPES DE SOUZA, SERGIO AUGUSTO ; MAS MILIAN, FELIX ; XAVIER DA SILVA, ADEMIR . A New Approach for Radiosynoviorthesis: A Dose-Optimized Planning method Based on Monte Carlo Simulation and Synovial Measurement Using 3D Slicer and MRI. MEDICAL PHYSICS, v. 1, p. 1, 2017. 9.

Thomas, Sylvia; GABRIEL, M. C. ; de Souza, S. A. L. ; GOMES, S. C. ; ASSI, P. E. ; PINHEIRO PERRI, M. L. ; Liberato, W. ; MATUSHITA, C. S. ; GUTFILEN, B. ; DA FONSECA, L. M. B. . 90Yttrium-hydroxyapatite: a new therapeutic option for radioactive synovectomy in haemophilic synovitis. Haemophilia (Oxford. Print), v. 1, p. no-no, 2011.

Current Positions/Chairs:

  • Professor
    Department of Radiology, Federal University of Rio de Janeiro
  • Member
    MSK committee of the World Federation of Hemophilia
  • Responsible for the Radiosynovectomy team
    Nuclear Medicine Department in the Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro

Key Institutions

  • Federal University of Rio de Janeiro
    Department of Radiology
    Rio de Janeiro, Brazil
  • Clementino Fraga Filho University Hospital (HUCFF UFRJ)
    Nuclear Medicine Service
    Rio de Janeiro, Brazil

Research Activities

  • Future research: Clinical Trial (RCT) double-blind with platelet rich plasma, hyaluronic acid and mesenchymal cells for the treatment of arthropathy now waiting for Ethical Board Committee approval
  • Clinical Trial (RCT), double-blind comparing radiosynovectomy and triamcinolone in advanced arthropathy, ready to start, already approved by the Ethical Board Committee approval

Research Interests

  • Use of radiosynoviorthesis procedures in patients with hemophilia
  • Minimal invasive therapies for hemophilic arthropathy.
  • Outcome measures for prophylaxis, including non-factor therapies (emicizumab mainly)
  • Radioisotopes for therapy of hemophilic arthropathy – tailored doses for synovitis


  • Continuous support from the UFRJ and its University Hospital, to the minimal invasive therapies and research to hemophilia patients from all over Brazil, without costs to the patients